Tumors?

[YungRasputin]

dubious source i realize however i was wondering if anyone saw this and/or recognize what this malady could be? species is Augacephalus ezendami or Mozambique Baboon - also find it curious that this dude has so many bizarre and exotic illnesses concentrated in his collection but perhaps this is another thread

the vid:

 

[KaroKoenig]

Ah well... Exotics Lair. Wha'ever.

 

[Hakuna]

Could be several things. Could have been WC. Could have been his terrible husbandry and ignorance. Who knows?

You can bet he will make a dramatic video about it, though. That’s a sure thing.

 

[BoyFromLA]

I am not going to click and watch the video, due to not wanting to partake in adding more view counts to it, though I am curious to know what’s the main cause of this ‘tumor’.

 

[Neonblizzard]

The guy has 150 specimens that all have impaction, nematodes, tumours, "DKS" and legs that need amputating...

 

[YungRasputin]

for those that don’t want to click on the vid (and hopefully this will be permitted)

 

[BoyFromLA]

for those that don’t want to click on the vid

So this ‘tumor’ looks to be developed on one of the spinnerets, am I correct? If it is, then it’s very new / unheard / unseen for me. Most of the ‘tumor’ spots I saw from others were nearby book lungs, left / right / under side of abdomen.

 

[YungRasputin]

So this ‘tumor’ looks to be developed on one of the spinnerets, am I correct? If it is, then it’s very new / unheard / unseen for me. Most of the ‘tumor’ spots I saw from others were nearby book lungs, left / right / under side of abdomen.

yes, you’re right and further, in the video is appeared to be squishy to the touch when he was feeling it out - which i thought was somewhat odd

after posting this i have researched the topic a little and haven’t found much on the existence and/or prevalence of tumors in spiders or arachnids more generally

 

[Jonathan6303]

Is this prevalent in wc species? Never heard of this before only nematodes.

 

[YungRasputin]

Is this prevalent in wc species? Never heard of this before only nematodes.

I’m at work rn and would have to rewatch the video to see if he specified - this being said they’ve talked about and have done a lot of videos about trading, breeding, etc so it may be CB, hard to say

 

[Hakuna]

Is this prevalent in wc species? Never heard of this before only nematodes.

There are other parasites that cause large bumps. Wouldn’t be surprised if it was in the spinneret.

I’m at work rn and would have to rewatch the video to see if he specified - this being said they’ve talked about and have done a lot of videos about trading, breeding, etc so it may be CB, hard to say

Wouldn’t trust anything he has to say, anyway. He’s a joke.

 

[YungRasputin]

Wouldn’t trust anything he has to say, anyway. He’s a joke.

I don’t however realistically all we have to go on is what’s presented in the video - the fact that the, let’s say, abnormal growth on the spinneret seems squishy leads me to think it could be a possible parasite as cancerous tumors are usually hard/firm to the touch

 

[8 legged]

...naturally malignant cells can also proliferate in tarantulas, but this is not new...

 

[YungRasputin]

...naturally malignant cells can also proliferate in tarantulas, but this is not new...

yes, of course - tho i’m curious about differences in frequency and prevalence between mammals and arachnids/inverts

 

[8 legged]

As far as I know, there are no works and figures on this, but the mammal (especially we two-leggeds) should be clearly in the lead due to the large number of risk factors.

 

[DaveM]

yes, of course - tho i’m curious about differences in frequency and prevalence between mammals and arachnids/inverts

As far as I know, there are no works and figures on this, but the mammal (especially we two-leggeds) should be clearly in the lead due to the large number of risk factors.

Lobsters are under study for their great longevity and resistance to cancer -- the mechanisms of resistance are not yet known.
One usual suspect, the tumor suppressor p53 pathway: they found surprisingly that Lobsters do not have as many components of the p53 pathway.
(see figure 5 in this paper: https://www.science.org/doi/10.1126/sciadv.abe8290)
(and a news article https://www.science.org/news/2021/0...y-sequenced-genome-could-reveal-their-secrets)
There are so many other possibilities, many other pathways.
Tarantula genomes have been sequenced too. With time, we could match up genes between tarantulas, lobsters, and humans to try to get some idea of how cancerous cells are eliminated (or fail to be eliminated).

I'm interested as @YungRasputin is -- great namesake, by the way! Rasputin was hard to kill.
With you @8 legged that we two leggeds have so many known cancer risks, such a high prevalence, and our spiders: we understand so little, and tumors might be so uncommon, that we have little to learn from except maybe genetic analysis.

 

[viper69]

Lobsters are under study for their great longevity and resistance to cancer -- the mechanisms of resistance are not yet known.
One usual suspect, the tumor suppressor p53 pathway: they found surprisingly that Lobsters do not have as many components of the p53 pathway.
(see figure 5 in this paper: https://www.science.org/doi/10.1126/sciadv.abe8290)
(and a news article https://www.science.org/news/2021/0...y-sequenced-genome-could-reveal-their-secrets)
There are so many other possibilities, many other pathways.
Tarantula genomes have been sequenced too. With time, we could match up genes between tarantulas, lobsters, and humans to try to get some idea of how cancerous cells are eliminated (or fail to be eliminated).

I'm interested as @YungRasputin is -- great namesake, by the way! Rasputin was hard to kill.
With you @8 legged that we two leggeds have so many known cancer risks, such a high prevalence, and our spiders: we understand so little, and tumors might be so uncommon, that we have little to learn from except maybe genetic analysis.

However, p53 is not the only player you know this. It's the most commonly looked at though because of its high involvement. Google p53 and elephants and you will find they have a heap of p53 for their size.

Sick and tired of everyone calling a spherical enlargement a TUMOR. It could be a fluid filled space ie cyst. I believe it to be fluid filled because Ts have an open circulatory system. Perhaps their circulation goes out of whack.

 

[DaveM]

However, p53 is not the only player you know this.

Yes.

There are so many other possibilities, many other pathways.

It's the most commonly looked at though because of its high involvement. Google p53 and elephants and you will find they have a heap of p53 for their size.
Sick and tired of everyone calling a spherical enlargement a TUMOR. It could be a fluid filled space ie cyst. I believe it to be fluid filled because Ts have an open circulatory system. Perhaps their circulation goes out of whack.

Couldn't agree with you more.
It's a challenge not wanting to do experiments on, or dissect, a precious pet. I would otherwise want to probe cysts, to see if they are fully encapsulated or have any remaining connection to the systemic circulation, to take sections and look what sort of cells line the cysts, to see what constituents are present in the lumen of a cyst. I agree completely that people are far too quick to jump to the conclusion that abnormal lumps must be cancer.
The p53 in elephants: I saw that study too, the idea being that elephants are so large that they have so many cells and so many cell divisions. That's many more chances for replication errors and mutation from other sources -- yet, cancer is so rare in them. How can such a large animal police so many cells to stop tumors from forming? p53 was an answer for elephants (for those who don't know, p53 causes damaged pre-cancerous cells to commit suicide, sparing the creature from tumor formation). p53 seems (tentatively, not firmly established) not to be the answer for lobster longevity, plenty of other candidates (especially telomeres!). But toward the opposite end of the size spectrum from elephants, perhaps small creatures like insects and spiders have less need of tumor suppression because they have far fewer cells that could potentially go awry (and many of them have short lifespans, less time for mutations to accumulate).