Sicarius thomisoides (Six Eyed Sand Spider) Venom?

[Brewser]

Many different types of Venom.
criticism 'May' be construed as spiteful and venomous as well

 

[MorbidArachnid]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694614/

Link to them actually testing Sicarius thomisoides venom and demonstrating it's ability to produce a necrotic lesion in rabbits. Venom potency is a lot of things, there's the volume of venom injected (which Sicarius can produce and inject more metric volume of venom because of their larger size), there's the concentration of the protein that causes detrimental effects (which in Sicariidae is the Phospholipase D protein, and this is where most of the statements about Sicarius and Hexophthalma potency come from because they do seem to have higher concentrations of this protein than Loxosceles do as a whole), and then there's the activity level of that protein. You can have a lot of venom injected at a very high concentration of protein and still have only mild effects because the protein didn't interact with any of your cells. Maybe the protein is a different isoform that can't bind to the receptors as well, or there aren't receptors at all, or maybe your body is just really good at isolating and neutralizing the venom before it has any serious effect. I don't know if any of these apply to Sicarius venom, but the paper does suggest Sicarius thomisoides has a lower activity level of protein than Loxosceles laeta. That being said, the venom still caused hemolytic and cytotoxic effect on human cells in a petri dish and caused a small lesion on rabbits, so it clearly can cause necrotic lesions and should still be treated as medically significant. I also think that the general reports of it rotting your arm off are largely exaggerated. I still haven't been able to find any primary or solid sources on what the human bite reports actually are for Hexophthalma, some papers say there was only one confirmed bite and the person lost an arm, some say he died, some say it wasn't confirmed but suspected based on the description of the spider, some say there was one bite where someone lost an arm and another bite that was a death, some say three confirmed bites. Does anyone have the actual case report for any of these? Even trying to track back through the sources I'm not getting anything. Like I see where they're cited at the bottom of papers but I can't find the original sources, at least one of them on a bite of a Sicarius tropicus is in Portuguese.