Changing substrate that often leads to T stress. T's in their natural habitat can live in the same undalterated 5 square feet for 30 years ! Listen to people like Talkenlate04. Unless you have something that threatens your T ( molds or mites ) leave them be. Spot cleaning is all you need to do on a regular basis.I do a substrate change around every 2-4 months. Just depends on whether it looks like it needs it or not.
Never. Unless of course there is some sort of infestation.